nanoScan® PET/CT

nanoScan® PET system

The nanoScan® PET system is equipped with the finest detector crystal needles ensuring high spatial resolution down to 700 μm in vivo.
Quantitative results delivered over the widest range of radioactivity levels from 60 Bq to 60 MBq (1.6 nCi – 1.6 mCi). It covers the full range of PET applications from long-term cell tracking to dynamic studies with ¹¹C- and ¹⁵O-labelled radiotracers in rats.
Large ring diameter allows imaging of multiple mice and large animals, while the unique, Tera-Tomo™ 3D iterative reconstruction based on real-time Monte Carlo simulation ensures homogeneous image quality over the entire field of view.
Open access to the animal during PET scanning gives full control over the animal studies.
The PET system is also available in triple-modality combination with our high-end SPECT (nanoScan SPECT/CT/PET) or fully integrated with MRI (nanoScan PET/MRI).

Resolving precise details with 700 μm spatial resolution

• Finest lutetium oxyorthosilicate (LSO) crystal needles provide precise signal localization preserving spatial information in raw data
• Tera-Tomo™ 3D PET iterative reconstruction with real-time Monte Carlo based physical modelling unveiling the tiniest details on the image
• Large ring diameter and statistical depth of interaction compensation offers homogeneous image quality over the entire field of view

Uncompromised applications with very low level of radioactivity

• Thick LSO crystals for excellent sensitivity
• Advanced corrections (random, scatter, LSO background etc.) ensuring quantification at low activity levels
• Best on the market minimal detectable activity: 60 Bq (1.6 nCi)
• Inherently optimized for longitudinal studies e.g. long-term cell tacking

Coping with count rate: mastering studies with high dose

• Multichannel read-out electronics with ultra-fast data processing and advanced dead-time correction
• Exceptional count rate performance – peak Noise Equivalent Count Rate (NECR) for mouse is 850 kcps @ 60 MBq
• Fully quantitative at 60 MBq (1.6 mCi) and beyond
• Suitable for dynamic imaging of large animals or for dynamic scanning of up to four mice simultaneously
• Optimal for imaging of isotopes with short half-life (e.g. ¹¹C, ¹³N, ¹⁵O etc.)

Largest transaxial field of view

• Wide bore diameter of 16 cm allowing open access to the animals
• Large transaxial field of view of 12 cm
• Excellent homogeneity over the entire field of view
• Suitable for various animal models from tiny mouse to large rabbits (6.5 kg)
• Simultaneous multiple animal imaging (up to 4 mice or 2 rats) with individual physiological monitoring function

Excellent image quality and quantitation accuracy with the Tera-Tomo™ image reconstruction

• 3D iterative reconstruction applying deep Monte Carlo based physical modelling of particle-level interaction from positron emission to detection
• Advanced corrections for energy, time, dead-time and random events and positron range
• CT or MR based attenuation and scatter correction
• Readily available acquisition and reconstruction protocols optimized for wide range of applications
• Automated workflow with 4D multiparametric PET reconstruction for fast kinetic analysis of dynamic acquisitions.

High power CT with large field-of-view and high resolution

• Up to 80 W X-ray power enables high-performance scanning even for large or multiple animals
• Variable magnification for high-resolution imaging with 10 μm isotropic voxel size
• Very high throughput: fast scanning with real-time image reconstruction combined with multiple animal imaging capability
• Iterative image reconstruction for low-noise and low-dose imaging
• Ultra-low-dose protocol for follow-up studies with only 1 mSv whole-body dose to the animal
• Imaging with cardiac and respiratory gating